2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Checkpoint Kinase (Chk)
  5. Checkpoint Kinase (Chk) Isoform
  6. Checkpoint Kinase (Chk) Activator

Checkpoint Kinase (Chk) Activator

Checkpoint Kinase (Chk) Activator (1):

Cat. No. Product Name Effect Purity
  • HY-172915
    p53 Stabilizer 2
    		Activator
    p53 Stabilizer 2 (Compound 17a16) is a p53 stabilizer. p53 Stabilizer 2 induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells. p53 Stabilizer 2 induces mitochondrial stress and activates two checkpoint pathways: NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. p53 Stabilizer 2 inhibits tumor growth in p53-deficient xenograft model.